Properdin in complement activation and tissue injury

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Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury.

The alternative pathway (AP) of complement activation is constitutively active and must be regulated by host proteins to prevent autologous tissue injury. Dysfunction of AP regulatory proteins has been linked to several human inflammatory disorders. Properdin is a positive regulator of AP complement activation that has been shown to extend the half-life of cell surface–bound C3 convertase C3bBb...

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Activation of complement represents one means of natural resistance to infection from a wide variety of potential pathogens. Recently, properdin, a positive regulator of the alternative pathway of complement, has been shown to bind to surfaces and promote complement activation. Here we studied whether properdin-mediated complement activation occurs on the surface of Chlamydia pneumoniae, an obl...

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Complement activation by tubular cells is mediated by properdin binding.

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Quantitative Studies on the Properdin-complement System

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ژورنال

عنوان ژورنال: Molecular Immunology

سال: 2013

ISSN: 0161-5890

DOI: 10.1016/j.molimm.2013.06.002